Coffee and Its Benefits

 

Coffee is a brewed drink prepared from roasted seeds, called coffee beans, of the coffee plant. Coffee beans are found in coffee cherries, which grow on trees in over 70 countries, cultivated primarily in Latin America, Southeast Asia, and Africa. 'Green Unroasted' coffee is one of the most traded agricultural commodities in the world. Coffee can have a stimulating effect on humans due to its caffeine content. It is one of the most-consumed beverages in the world.

Benefits of coffee

All-cause mortality

In women, coffee consumption significantly decreases all-cause mortality, apparently decreasing somewhat linearly to a relative risk of approximately 0.85 for those drinking 3 cups per day compared to those who consume no coffee, but the relative risk then remains almost the same for up to 6 cups per day, according to a large prospective cohort study. In men, these beneficial effects were not as great, in fact with an increased risk for those drinking approximately one cup every other day compared to those drinking none, but yet having a significant trend towards less mortality for those who drink more than 2 cups per day compared to those who drink none. Results were similar for decaffeinated coffee.

Reduced risk of Alzheimer's disease and Dementia

Several studies comparing moderate coffee drinkers (defined as 3-5 cups per day) with light coffee drinkers (defined as 0-2 cups per day) found that those who drank more coffee were significantly less likely to develop Alzheimer's disease later in life. A longitudinal study in 2009 found that moderate coffee drinkers had reduced risk of developing dementia in addition to Alzheimer's disease.

Reduced risk of gallstone disease

Drinking caffeinated coffee has been correlated with a lower incidence of gallstones and gallbladder disease in both men and women in two studies performed by the Harvard School of Public Health. A lessened risk was not seen in those who drank decaffeinated coffee. A recent study showed that roast coffee protected primary neuronal cells against hydrogen peroxide-induced cell death.

Reduced risk of Parkinson's disease

A study comparing heavy coffee drinkers (3.5 cups a day) with non-drinkers found that the coffee drinkers were significantly less likely to contract Parkinson's disease later in life. Likewise, a second study found an inverse relationship between the amount of coffee regularly drunk and the likelihood of developing Parkinson's disease.

Cognitive performance

Many people drink coffee for its ability to increase short term recall.

Likewise, in tests of simple reaction time, choice reaction time, incidental verbal memory, and visuospatial reasoning, participants who regularly drank coffee were found to perform better on all tests, with a positive relationship between test scores and the amount of coffee regularly drunk. Elderly participants were found to have the largest effect associated with regular coffee drinking. Another study found that women over the age of 80 performed significantly better on cognitive tests if they had regularly drunk coffee over their lifetimes.

Analgesic enhancement

Coffee contains caffeine, which increases the effectiveness of pain killers, especially migraine and headache medications. For this reason, many over-the-counter headache drugs include caffeine in their formula.

Antidiabetic

Coffee intake may reduce one's risk of diabetes mellitus type 2 by up to half. While this was originally noticed in patients who consumed high amounts (7 cups a day), the relationship was later shown to be linear.

Liver protection

Coffee can also reduce the incidence of cirrhosis of the liver and has been linked to a reduced risk of hepatocellular carcinoma, a primary liver cancer that usually arises in patients with preexisting cirrhosis. The exact mechanism and the amount of coffee needed to achieve a beneficial effect have long been unclear. The cytokine transforming growth factor (TGF) beta has long been recognized for promoting fibrosis ability acting through the Smad family of transcription factors. In an interesting report recently published in the Journal of Hepatology, Gressner and colleagues provide the first mechanistic context for the epidemiological studies on coffee drinkers by showing that caffeine may have potent anti-fibrotic capabilities through its ability to antagonize the Smad pathway.

Cancer

Coffee consumption is also correlated to a reduced risk of oral, esophageal, and pharyngeal cancer. In ovarian cancer, no benefit was found. In the Nurses' Health Study, a modest reduction in breast cancer was observed in postmenopausal women only, which was not confirmed in decaffeinated coffee. According to one study, coffee protects the liver from cancer. Another preliminary study found a correlation between coffee consumption and a lower risk of aggressive prostate cancer.

Cardioprotective

Coffee moderately reduces the incidence of dying from cardiovascular disease, according to a large prospective cohort study published in 2008. A 2009 prospective study in Japan following nearly 77,000 individuals aged 40 to 79 found that coffee consumption, along with caffeine intake, was associated with a reduced risk of dying from cardiovascular disease.

Laxative/diuretic

Coffee is also a powerful stimulant for peristalsis and is sometimes considered to prevent constipation. However, coffee can also cause excessively loose bowel movements. The stimulative effect of coffee consumption on the colon is found in both caffeinated and decaffeinated coffee.

Practitioners in alternative medicine often recommend coffee enemas for "cleansing of the colon" due to its stimulus of peristalsis, although medicine has not proven any benefits of the practice.

Contrary to popular belief, caffeine does not act as a diuretic when consumed in moderation, and does not lead to dehydration or to a water-electrolyte imbalance; current evidence suggests that caffeinated beverages contribute to the body's daily fluid requirements no differently from pure water.

Antioxidant

Coffee contains the anticancer compound methylpyridinium. This compound is not present in significant amounts in other food materials. Methylpyridinium is not present in raw coffee beans but is formed during the roasting process from trigonelline, which is common in raw coffee beans. It is present in both caffeinated and decaffeinated coffee, and even in instant coffee. A recent study shows that roast coffee contains more lipophilic antioxidants and chlorogenic acid lactones and are more protective against hydrogen peroxide-induced cell death in primary neuronal cells than green coffee.

Prevention of dental caries

The tannins in coffee may reduce the cariogenic potential of foods. In vitro experiments have shown that these polyphenolic compounds may interfere with glucosyltransferase activity of mutans streptococci, which may reduce plaque formation.

Gout

Coffee consumption decreased risk of gout in men over age 40. In a large study of over 45,000 men over a 12-year period, the risk for developing gout in men over 40 was inversely proportional with the amount of coffee consumed.